Dr. Malek’s

MTHFRSolve

For people who’ve tried everything.

Here’s (almost) everything I offer:

  • Methylation Genetics + Personal Video Analysis/Supplement Plan

    Get a check swab to see how your genes affect methylation, detox, and energy pathways (including MTHFR and COMT, of course) and I’ll record myself analyzing your results and producing your supplement plan on my screen.

    Get your cheek swab

  • Mood Genetics + Personal Video Analysis/Supplement Plan

    This is a cheek swab too, but the genes tested are targeted towards things that affect serotonin, dopamine, and stress chemistry (and therefore anxiety, low mood, irritability, or sleep disruption). Also includes a video analysis.

    Get your cheek swab

  • Methylation Genetics + Biomarkers + Live Consult

    Cheek swab (genetics) + Blood test (methylation biomarkers) + live 45-minute consult to talk about what it all means.

    Get your cheek swab + blood draw pack

  • Upload Your Data + Personal Video Analysis

    Upload any genetic data, blood labs, etc. that you have and I’ll study all of it and produce a screenshare video analysis with my thoughts.

    Upload your data

  • Consult (30 - 60 minutes)

    Schedule a live video consult with me. You’ll have the opportunity to upload any data/history you want me to see beforehand.

    Check the schedule

Testimonials from my beloved clients and patients:

“Confirmed lifelong issues that doctors were unwilling or could not fix…”

~ Michael

“This level of guidance is rare to find.”

~ Anonymous customer

“Far superior to the more expensive offering from the competition! :-)”

~ Todd

“This is the best genetic testing kit on the market.”

~ Dexter

“This is honestly already the best help I’ve ever gotten.”

~ Wellness Client from North Carolina

“Putting aside earning money fast so they can focus on the tests they already have proves to me that money isn't their first concern, health is.”

~ Debbie

“I really don’t have faith in anyone else being able to do what you do and help me like you have.”

~ Wellness Client from California

Disclaimer: The testimonials displayed on this website reflect individual client experiences with either licensed medical care or educational wellness services. Medical services are available only to residents of states where Dr. Malek is licensed to practice (currently Florida, Texas, Arizona, and Minnesota). Educational services offered to clients in other regions are not medical care, do not establish a doctor-patient relationship, and are not intended to diagnose, treat, cure, or prevent any disease. Individual results vary, and no outcome is guaranteed.

About me:

Dr. Malek Hamed

MTHFRSolve is my brainchild.

I’m an IFM-trained Functional Medicine physician* with experience solving a wide variety of disorders still seen as mysterious by the modern medical paradigm.

I love solving those mysterious problems.*

But doing so requires two things that are, unfortunately, much too rare in our times: Authenticity and Depth.

MTHFRSolve is my way of bringing those back.

~ Dr. Malek
support@malekmd.com

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*If you live in a state where I’m licensed, I offer full-spectrum online medicine services. If you're outside those regions, I provide non-medical wellness consultations designed to help you unlock what’s holding you back, using your genetics, labs, and unique biology.

I started this ultra-small, Florida-based company with the aim of providing the most in-depth, scientifically accurate, and personalized genetic and functional guidance possible.

I enforce the following rigorous standards upon my tiny team:

~ Your Health Data Stays PRIVATE~
I follow strict confidentiality standards so your information is never shared unless you ask for it. I consider that immoral.

~ Expert Interpretation & Strategy ~
Every insight, plan, and recommendation comes directly from me, a highly-trained MD, not a script or assistant.

~ Actionable Guidance ~
I won’t just send you numbers. I’ll teach you what they mean and how to use them to improve your health.

~ Super Convenient, Accessible Process ~
Whether genetic kits, lab orders, or follow-up consults, I will absolutely try my best to make things as easy as possible for you all.

Note: Genetic and functional testing services are provided via third-party laboratories. Interpretation is for educational and wellness purposes and does not constitute medical advice unless delivered through a licensed medical consultation in an eligible state.

If you’re here for methylation, get my Comprehensive Methylation Panel:

“Wow, All I can say is this test has been incredibly helpful for both my daughter and my wife. It’s uncovered some major issues that we had not been able to diagnose with standard tests.”
— One of my clients

*FL, TX, AZ, and MN ONLY

MTHFRSolve Comprehensive Methylation Panel + COMT

One of the most comprehensive tests of methylation genetics on the market. Learn more

  • We test 26 spots on your DNA that are relevant to the process of methylation, including MTHFR, MTR, MTRR, AHCY, and more. Many competitors test only 5.

  • We test the highly important COMT gene SNP, a gene that affects how you process dopamine, adrenaline, and estrogen.

  • Your results come with in-depth supplement recommendations, including dosages, recorded over video by Dr. Malek (me) for your unique genetic variances.

MTHFRSolve Comprehensive Methylation Panel + COMT Testing
Sale
MTHFRSolve Comprehensive Methylation Panel + COMT Testing
$499.00 $549.00

“Wow, All I can say is this test has been incredibly helpful for both my daughter and my wife. It’s uncovered some major issues that we had not been able to diagnose with standard tests.”
— One of our clients

Get $100 OFF when you order three kits (automatically applied at checkout)

Check out the sample report here.

My Comprehensive Methylation Panel + COMT testing is one of the most in-depth genetic methylation tests on the market. This test looks at 26 gene SNPs that are highly relevant to the process of methylation. This has the potential to help you fix your:

  • Chronic fatigue

  • Memory issues

  • Mood issues

  • Migraines

  • Detox issues

  • Chronic allergies and hypersensitivities

  • And much more.

Your genetic results include a summary with personalized supplement recommendations written by our head physician, Dr. Malek (optional).

Get your results in 5 steps:

  1. Order your kit.

  2. Receive your kit, usually within 5-7 business days via USPS (tracking information provides upon shipment).

  3. Perform your cheek swab.

  4. Mail your kit back to the lab (free return shipping label included).

  5. Get your results sent to your email with personalized recommendations based on your genetics (approximately 2-3 weeks after we receive your sample in the lab).

This is one of the most comprehensive methylation tests available—for one of the lowest prices out there. It offers much more than just a basic MTHFR test. Full list of gene SNPs (with exact rsids) below!

Learn more about why it’s so important to test for more than just MTHFR.

Consider ordering this test along with Mood.

NOTE: If you buy multiple kits for one person (e.g. the Methylation Panel and the Mood Panel), I will consider all data and produce a single report that takes everything into account.

Not sure if this kit is right for you? Email us

Genes (with exact rsids):

  • AHCY (rs13043752)

  • BHMT (rs3733890)

  • CBS (rs234706)

  • CUBN (rs1801222)

  • DHFR (rs70991108)

  • FOLR1 (rs2071010)

  • FOLR2 (rs651933)

  • GC (rs2282679)

  • MAT1A (rs7087728)

  • MTHFD1 (rs2236225)

  • MTHFR: A1298C (rs1801131)

  • MTHFR: C677T (rs1801133)

  • MTHFS (rs898436)

  • MTR (rs1805087)

  • MTRR: A66G (rs1801394)

  • MTRR: A664A (rs1802059)

  • NFE2L2 (rs6721961)

  • NPC1L1 (rs2072183)

  • NQO1 (rs1800566)

  • PPARGC1A (rs8192678)

  • SIRT1 (rs1467568)

  • SLC19A1 (rs1051266)

  • SOD2 (rs4880)

  • TCN1 (rs526934)

  • TCN2 (rs1801198)

  • TFAM (rs1937)

  • VDR (rs2228570)

  • COMT (rs4680)

“Thank you so much again for your patience, persistence and thoroughness…

So far, you're the only clinician I've worked with to date who's been able to move the needle on my various issues, and it's hard to express in words how thankful I am for that!”

— Former Client

If you want open-ended help, schedule a consult:

*FL, TX, AZ, and MN ONLY (others click HERE)

Book a consultation

(I don’t treat insurance codes...)

If you’ve already seen five specialists, tried dozens of protocols, or been told repeatedly that “your labs look fine”…

Then welcome!

I work with people who are stuck in that exact place.

Whether it’s methylation dysfunction, neurotransmitter imbalance, fatigue, anxiety, food reactions, chronic toxicities, chronic viral injury, or symptoms no one can explain—I help patients unravel complex cases by developing the fullest biochemical picture possible.

These are not generic visits. You’ll get:

  • A full review of your history, symptoms, and prior labs

  • Integration of genetics, nutrition, lifestyle, and targeted biomarkers

  • Real strategy, grounded in your physiology—not insurance codes, CPT billing, or (frankly) broken algorithms.

ONLY for residents of Florida, Texas, Arizona, and Minnesota. (CLICK HERE for international customers and other US states! 🌍)

This is for you if:
You’re exhausted by formulaic medicine, you suspect something deeper is going on, and you want to paint the fullest picture of your current health possible.

“What a great program! The testing was simple and the results came back very quickly.”

— Todd

Or go back up and check out all my offerings:

Back to offerings ⬆

You can also check out my blog:

Featured
Fatigue from Slow COMT: The Fundamental Cause and How to Get More Energy
Malek Hamed, MD
Fatigue from Slow COMT: The Fundamental Cause and How to Get More Energy
Malek Hamed, MD

5th question I received:

“I would like to find out more about the fatigue caused by the slow COMT gene and how to fix it thank you.”

Read more →
Malek Hamed, MD
If you don’t tolerate glycine, consider this deficiency.
Malek Hamed, MD
If you don’t tolerate glycine, consider this deficiency.
Malek Hamed, MD

This also applies if you don’t tolerate collagen and bone broth (which contain a lot of glycine), but there could be other reasons in those two cases.

Glycine is an extremely important amino acid involved in the production of connective tissue (hair/skin/nails/bones), detoxification pathways, sleep, and brain function. And almost everyone eating a modern diet is deficient.

Read more →
Malek Hamed, MD
Post-Partum and Post-Lactation Health Optimization
Malek Hamed, MD
Post-Partum and Post-Lactation Health Optimization
Malek Hamed, MD

4th question I received:

“Post partum recovery: After I stopped lactation. Cholesterol and triglycerides were elevated, and my sex hormones levels (estrogen, testosterone, and progesterone) were low. What is the best way to restore (revitalize, replenish, etc.) back to my pre pregnancy levels?”

Read more →
Malek Hamed, MD
How Can Someone Be B6 Deficient and B6 Toxic at the Same Time?
Malek Hamed, MD
How Can Someone Be B6 Deficient and B6 Toxic at the Same Time?
Malek Hamed, MD

3rd question I received:

“How can someone be both cellularly deficient in B6 while also being b6 toxic, and what are the methylation issues potentially preventing healthy utilization regardless of the form ingested?”

Read more →
Malek Hamed, MD
Do Antihistamines Treat Undermethylation, MTHFR Dysfunction, Slow COMT?
Malek Hamed, MD
Do Antihistamines Treat Undermethylation, MTHFR Dysfunction, Slow COMT?
Malek Hamed, MD

2nd question I received:

“I know people having relief and enhanced health following the use of antihistamine drugs. Do these treat root cause or only remedy a piece of the puzzle of what’s happening inside body?”

Read more →
Malek Hamed, MD
Do You Ever Stop MTHFR Supplements? When Nutrients Can Be Temporary vs Lifelong
Malek Hamed, MD
Do You Ever Stop MTHFR Supplements? When Nutrients Can Be Temporary vs Lifelong
Malek Hamed, MD

1st AMA question I received:

“Once you support deficiencies and associated pathways with certain nutrients will you no longer need to take those supplements? Will the body be become independent of those supports over time or, because of certain genetic issues, will support always be needed?”

Read more →
Malek Hamed, MD
Slow COMT, Menopause, and Insomnia
Malek Hamed, MD
Slow COMT, Menopause, and Insomnia
Malek Hamed, MD

Estrogen affects the way that your body processes neurotransmitters, i.e. those molecules that signal within your brain and skew it towards different “modes” of cognition and function. With regards to sleep, specifically, estrogen reduces

Read more →
Malek Hamed, MD
Don’t Take DIM if You Have Slow COMT (until you fix it)
Malek Hamed, MD
Don’t Take DIM if You Have Slow COMT (until you fix it)
Malek Hamed, MD

One of the more common mistakes made by people with estrogen dominance is taking DIM by itself (and note that this can include postmenopausal women on HRT/Hormone Replacement Therapy).

Read more →
Malek Hamed, MD
The Low B6 Diet Is Not Effective for B6 Toxicity
Malek Hamed, MD
The Low B6 Diet Is Not Effective for B6 Toxicity
Malek Hamed, MD

Hello all. Dr. Malek here. Because I’m aware that this article has the potential to be highly inflammatory, I have to caveat as follows:

  1. I have directly treated more B6 toxic patients than nearly any other doctor/provider in the world.

  2. I am an allopathic MD, i.e. a “normal” doctor. I’m not a chiropractor (though I have much respect for them) nor an ND, NP, healthfluencer, or anything else.

…

Read more →
Malek Hamed, MD
Magnesium Glycinate Problematic for Slow COMT?
Malek Hamed, MD
Magnesium Glycinate Problematic for Slow COMT?
Malek Hamed, MD

“You can’t take magnesium glycinate with slow COMT.”

I’ve personally encountered some skepticism, like the above, regarding magnesium glycinate and Slow COMT, namely that magnesium glycinate can actually worsen Slow COMT symptoms.

Read more →
Malek Hamed, MD
Grace…
Malek Hamed, MD
Grace…
Malek Hamed, MD
Read more →
Malek Hamed, MD
In this world of oil and steel…
Malek Hamed, MD
In this world of oil and steel…
Malek Hamed, MD

In this world of oil and steel, man is useful only insofar as he can fan the flames.

Read more →
Malek Hamed, MD
Tylenol, Autism, and Pregnancy—The Safe Way to Take it to Avoid the Potential Risk
Malek Hamed, MD
Tylenol, Autism, and Pregnancy—The Safe Way to Take it to Avoid the Potential Risk
Malek Hamed, MD

Recently, the FDA under the Trump administration took an initial step towards officially recognizing potential harms of Tylenol (acetaminophen, also called Paracetamol) supplementation during pregnancy.

The claim is that Tylenol has the potential to increase the risk of autism in the children of pregnant mothers who use it.

Read more →
Malek Hamed, MD
Slow COMT: The Definitive Clinical Guide for Testing and Optimization
Support @ MTHFRSolve
Slow COMT: The Definitive Clinical Guide for Testing and Optimization
Support @ MTHFRSolve

Slow COMT is a biochemical variant that can profoundly shape mood, stress tolerance, and even how you respond to vitamins or caffeine. If you’ve ever felt “tired but wired”— exhausted in body yet racing in mind—or found that B vitamins and coffee make you jittery and anxious, the slow COMT gene variant is very likely the hidden key.

In this comprehensive guide, we’ll show you clearly what COMT is (and the famous Val158Met polymorphism), how to identify a slow variant in your genetic data, and, most importantly, how to optimize your lifestyle and supplementation to feel better.

We’ll also highlight what to avoid (yes, there are “healthy” supplements that can backfire for slow COMT-ers). By the end, you’ll have a reasonably clear plan for managing a slow COMT.

Read more →
Support @ MTHFRSolve

FAQs

  • No. If you already have genetic data (from a test like 23andMe), you can upload it for analysis. If you don’t have any data yet and live in Florida, Texas, Arizona, or Minnesota, you can order one of our in-house test kits. If you're outside those states, you're still eligible for supplement plans or consultations based on data you already have — or based on your symptoms and goals, without any data at all.

  • If you ordered a supplement plan:
    You'll receive a secure upload form to submit your existing genetic data (and labs, if applicable). Once uploaded, Dr. Malek personally reviews your case and creates a phased plan tailored to your biology.

    If you ordered a test kit:
    You'll receive the kit within a few days. After your results are processed, Dr. Malek will build your supplement plan automatically — no upload or intake form required — and sent it to your email.

  • Only if you live in Florida, Texas, Arizona, or Minnesota. In those states, services may be delivered under Dr. Malek’s medical license. If you live elsewhere, your consultation or supplement plan will be provided for educational and wellness purposes only. Either way, you’ll receive in-depth, personalized guidance — always based on real data and careful analysis.

  • Use the guide above to choose based on your location and what data you already have. If you’re still unsure, just send us a quick message and we’ll help you decide.

  • Yes — we include detailed notes and instructions with every plan. However, if you need even more clarity or want to go deeper, you can always book a consultation afterward. Video consultations are not included, unless you get the Ultimate Methylation Package. For in-state clients, follow-up may fall under medical care depending on your situation.

  • These plans are for individuals who want a highly personalized supplement strategy based on their unique genetics and (optionally) labs and personal history. If you’ve felt unaddressed by one-size-fits-all protocols or experienced negative reactions to supplements in the past, this approach offers you a more targeted alternative.

  • Plan 1: Gene-Based Methylation Plan
    Focuses on specific SNPs that Dr. Malek uses in his in-house methylation and COMT panel. You’ll upload your raw genetic file (e.g. from 23andMe), and the plan will be based on those high-impact gene markers.

    Plan 2: Full Data Integration Plan
    Includes everything in Plan 1 — plus the option to submit recent labwork, background history, symptoms, and anything else you feel is relevant. The plan you receive reflects a deeper level of integration across your biology, not just your DNA.

  • You can upload your raw genetic data from services like 23andMe, AncestryDNA, or any other platform that allows access to your raw SNP data. We’ll provide a secure, HIPAA-compliant upload form after purchase.

    If for whatever reason we determine that your results simply are not sufficient for analysis, we will reach out to you with the option to either refund your payment or obtain further detail.

  • No. You can provide lab results if you choose the Full Data Integration version of the supplement plan or a Video Consultation and want them factored into your strategy. Otherwise, no lab results required.

  • You’ll typically receive your plan within 3–5 business days after uploading your data and completing the intake form. Full Data integration options may require up to 10 days, depending on case complexity.

  • For kits and supplement plans (unless otherwise noted), you’ll receive:

    • A phased supplement plan based on your data

    • Exact nutrient forms and dosages

    • Suggested timing and sequencing (e.g. Tier 1 → Tier 2)

    • Non-affiliated brand recommendations

    • Insights about your key SNPs and how they relate to your plan

  • These plans are designed to support your biology — not to diagnose or treat any disease. While many people experience improvements in energy, focus, mood, sleep, and many other symptoms, results vary and depend on multiple factors. What we offer is clarity, direction, and a highly strategic place to start.

  • Yes. You always have the option to book a consultation with Dr. Malek (medical or educational, depending on your location) to work on your health—with or without genetic data. These can be in the form of a follow-up to adjust your plan based on how you’re responding or if you want to go deeper. Consultations are not included with our supplement plans and kits, other than the Ultimate Methylation Package.

  • Reach out to admin@malekmd.com and we’ll be happy to help.

FAQs

(for the Comprehensive Methylation Panel)

  • Our test is conducted via the same method as Gary Brecka's test, i.e. via cheek swab. Gary Brecka's base 10X test covers 5 key methylation genes: COMT, AHCY, MTRR, MTR, and MTHFR. Our Comprehensive Methylation Panel + COMT testing kit includes over 20 genes to give you a deeper understanding of what nutritional, supplemental, and lifestyle changes you need to make to improve your methylation status.

  • There are no hidden fees. You pay a one-time flat-fee for your kit, and shipping is free. Your kit comes with a pre-included shipping label so you don’t have to pay for return shipping back to the laboratory.

  • Your sample is obtained via a simple cheek swab—the same as the method used by, for example, Gary Brecka’s cheek swab test.

  • There are a lot of supplements that can affect the way your body methylates: Things like methylcobalamin, methylfolate, magnesium, NAC, and much more. For some people, these will help, but for others, they can actually hurt. A better question is: What supplements will help my body with methylation? What does my body need to start methylating better. To figure that out, you need to get testing. Check out our genetic tests to get started.

  • Genetic testing is provided in collaboration with third-party labs. We generally collaborate with Fagron lab in Texas.

  • If there’s a SNP you’re wanting to test that you don’t see listed, just email us or give us a call. We have the capacity to test many different SNPs, including things like APOE, MAO-A/B, and much more.

  • For the genetic testing specifically, I serve all of Texas, Florida, Minnesota, and Arizona, so whether you’re in a bigger city like Houston, Dallas, Jacksonville, or Minneapolis, or a smaller town out in no-man’s land, you can get my genetic testing.

Still not sure where to begin? Contact us →

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Questions?

Send us an email and I (or my team) will do our best to get back to you.

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