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Fatigue from Slow COMT: The Fundamental Cause and How to Get More Energy
5th question I received:
“I would like to find out more about the fatigue caused by the slow COMT gene and how to fix it thank you.”
If you don’t tolerate glycine, consider this deficiency.
This also applies if you don’t tolerate collagen and bone broth (which contain a lot of glycine), but there could be other reasons in those two cases.
Glycine is an extremely important amino acid involved in the production of connective tissue (hair/skin/nails/bones), detoxification pathways, sleep, and brain function. And almost everyone eating a modern diet is deficient.
Post-Partum and Post-Lactation Health Optimization
4th question I received:
“Post partum recovery: After I stopped lactation. Cholesterol and triglycerides were elevated, and my sex hormones levels (estrogen, testosterone, and progesterone) were low. What is the best way to restore (revitalize, replenish, etc.) back to my pre pregnancy levels?”
How Can Someone Be B6 Deficient and B6 Toxic at the Same Time?
3rd question I received:
“How can someone be both cellularly deficient in B6 while also being b6 toxic, and what are the methylation issues potentially preventing healthy utilization regardless of the form ingested?”
Do Antihistamines Treat Undermethylation, MTHFR Dysfunction, Slow COMT?
2nd question I received:
“I know people having relief and enhanced health following the use of antihistamine drugs. Do these treat root cause or only remedy a piece of the puzzle of what’s happening inside body?”
Do You Ever Stop MTHFR Supplements? When Nutrients Can Be Temporary vs Lifelong
1st AMA question I received:
“Once you support deficiencies and associated pathways with certain nutrients will you no longer need to take those supplements? Will the body be become independent of those supports over time or, because of certain genetic issues, will support always be needed?”
Slow COMT, Menopause, and Insomnia
Estrogen affects the way that your body processes neurotransmitters, i.e. those molecules that signal within your brain and skew it towards different “modes” of cognition and function. With regards to sleep, specifically, estrogen reduces
Don’t Take DIM if You Have Slow COMT (until you fix it)
One of the more common mistakes made by people with estrogen dominance is taking DIM by itself (and note that this can include postmenopausal women on HRT/Hormone Replacement Therapy).
The Low B6 Diet Is Not Effective for B6 Toxicity
Hello all. Dr. Malek here. Because I’m aware that this article has the potential to be highly inflammatory, I have to caveat as follows:
I have directly treated more B6 toxic patients than nearly any other doctor/provider in the world.
I am an allopathic MD, i.e. a “normal” doctor. I’m not a chiropractor (though I have much respect for them) nor an ND, NP, healthfluencer, or anything else.
…
Magnesium Glycinate Problematic for Slow COMT?
“You can’t take magnesium glycinate with slow COMT.”
I’ve personally encountered some skepticism, like the above, regarding magnesium glycinate and Slow COMT, namely that magnesium glycinate can actually worsen Slow COMT symptoms.
Grace…
In this world of oil and steel…
In this world of oil and steel, man is useful only insofar as he can fan the flames.
Tylenol, Autism, and Pregnancy—The Safe Way to Take it to Avoid the Potential Risk
Recently, the FDA under the Trump administration took an initial step towards officially recognizing potential harms of Tylenol (acetaminophen, also called Paracetamol) supplementation during pregnancy.
The claim is that Tylenol has the potential to increase the risk of autism in the children of pregnant mothers who use it.
Slow COMT: The Definitive Clinical Guide for Testing and Optimization
Slow COMT is a biochemical variant that can profoundly shape mood, stress tolerance, and even how you respond to vitamins or caffeine. If you’ve ever felt “tired but wired”— exhausted in body yet racing in mind—or found that B vitamins and coffee make you jittery and anxious, the slow COMT gene variant is very likely the hidden key.
In this comprehensive guide, we’ll show you clearly what COMT is (and the famous Val158Met polymorphism), how to identify a slow variant in your genetic data, and, most importantly, how to optimize your lifestyle and supplementation to feel better.
We’ll also highlight what to avoid (yes, there are “healthy” supplements that can backfire for slow COMT-ers). By the end, you’ll have a reasonably clear plan for managing a slow COMT.
What Supplements Should I Take for Histamine Intolerance
Histamine intolerance can cause migraines, fatigue, gut problems, and skin reactions—without showing up on allergy tests. Here’s how to identify it, and what supplements can help you get relief without falling into common traps.
Should You Take Boswellia If You Have Slow COMT?
Boswellia is derived from the resin of a tree that's common through certain parts of Asia and Africa. People commonly use it for inflammatory issues, but I'm going to try to address whether this herb has any use and or harm for people with slow COMT variants specifically.
Slow COMT: The Ultimate Clinical Guide to Symptoms, Patterns, and Root Causes
Slow COMT function affects how the brain and body clear dopamine, norepinephrine, and estrogen—contributing to anxiety, fatigue, supplement intolerance, and poor sleep. This guide explains the full range of symptoms, why they’re often missed, and what works to stabilize those biochemical pathways.
What Supplements Should You Take if You Have a COMT Mutation?
Generally speaking, if you have a “mutation” in this gene, what that really means is that you have an under-functioning polymorphism that is less effective at breaking down dopamine, estrogen, and other metabolites…
Supplements to Avoid with a Slow COMT
As you may remember from our previous articles, catechol-O-methyltransferase (COMT) is an enzyme that breaks down catecholamines (most relevantly, dopamine), undesirable forms of estrogen, and other toxic substances in the body…
The Complete Guide to Vitamin B6 Toxicity Symptoms—Even Without Supplements
Vitamin B6 toxicity doesn’t just happen to people taking megadoses. Tingling feet, insomnia, anxiety, heart palpitations, and mysterious nerve symptoms can appear even at low daily intakes—sometimes without any supplements at all. This guide breaks down the full spectrum of B6 toxicity symptoms, from subtle sensory changes to life-altering neurological dysfunction, and explains why “normal” blood levels and doses may not be safe for everyone.