This short article has the potential to be highly impactful for the subset of people dealing with the following exact intersection of macroscopic bodily issues:

• GI issues (e.g. IBS, IBD, SIBO, slow digestive motility, etc.)

• post-exertional malaise (which we’ll call PEM, from now on, i.e. feeling real bad after exercise and other exertion),

• and migraines.

5th question I received:

“I would like to find out more about the fatigue caused by the slow COMT gene and how to fix it thank you.”

This also applies if you don’t tolerate collagen and bone broth (which contain a lot of glycine), but there could be other reasons in those two cases.

Glycine is an extremely important amino acid involved in the production of connective tissue (hair/skin/nails/bones), detoxification pathways, sleep, and brain function. And almost everyone eating a modern diet is deficient.

4th question I received:

“Post partum recovery: After I stopped lactation. Cholesterol and triglycerides were elevated, and my sex hormones levels (estrogen, testosterone, and progesterone) were low. What is the best way to restore (revitalize, replenish, etc.) back to my pre pregnancy levels?”

3rd question I received:

“How can someone be both cellularly deficient in B6 while also being b6 toxic, and what are the methylation issues potentially preventing healthy utilization regardless of the form ingested?”

2nd question I received:

“I know people having relief and enhanced health following the use of antihistamine drugs. Do these treat root cause or only remedy a piece of the puzzle of what’s happening inside body?”

1st AMA question I received:

“Once you support deficiencies and associated pathways with certain nutrients will you no longer need to take those supplements? Will the body be become independent of those supports over time or, because of certain genetic issues, will support always be needed?”

Estrogen affects the way that your body processes neurotransmitters, i.e. those molecules that signal within your brain and skew it towards different “modes” of cognition and function. With regards to sleep, specifically, estrogen reduces

One of the more common mistakes made by people with estrogen dominance is taking DIM by itself (and note that this can include postmenopausal women on HRT/Hormone Replacement Therapy).

Hello all. Dr. Malek here. Because I’m aware that this article has the potential to be highly inflammatory, I have to caveat as follows:

1. I have directly treated more B6 toxic patients than nearly any other doctor/provider in the world.

2. I am an allopathic MD, i.e. a “normal” doctor. I’m not a chiropractor (though I have much respect for them) nor an ND, NP, healthfluencer, or anything else.

…

“You can’t take magnesium glycinate with slow COMT.”

I’ve personally encountered some skepticism, like the above, regarding magnesium glycinate and Slow COMT, namely that magnesium glycinate can actually worsen Slow COMT symptoms.

In this world of oil and steel, man is useful only insofar as he can fan the flames.

Recently, the FDA under the Trump administration took an initial step towards officially recognizing potential harms of Tylenol (acetaminophen, also called Paracetamol) supplementation during pregnancy.

The claim is that Tylenol has the potential to increase the risk of autism in the children of pregnant mothers who use it.

Boswellia is derived from the resin of a tree that's common through certain parts of Asia and Africa. People commonly use it for inflammatory issues, but I'm going to try to address whether this herb has any use and or harm for people with slow COMT variants specifically.