MTHFR Gene Mutation Treatment by MTHFRSolve
Methylation and the MTHFR gene have burst onto the health and wellness scene—and for good reason. More people are starting to ask why they feel exhausted, foggy, anxious, or inflamed, even when standard lab work looks “normal.” If you’ve been told everything is fine when you clearly don’t feel fine, you’re not alone—and you’re not broken.
The truth is, your body isn’t the problem. Conventional care is.
Dr. Malek is here to help you move beyond outdated models of care with precision supplement plans and lifestyle support tailored to your unique genetic makeup. By treating MTHFR gene mutations, he can help you address the root causes of methylation issues.
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(For residents of TX, FL, AZ, MN)
(Residents of other states or international click here)
Do I Need a Supplement Plan? Symptoms of an MTHFR Gene Mutation
The first step of methylation treatment is to get tested. But you may already have genetic data from 23andme or a similar company. Or you might have already pinpointed a MTHFR gene mutation. If not, you want to start by listening to your body.
People with an MTHFR mutation may experience a wide variety of symptoms and chronic health issues, including:
Fatigue or low energy
Brain fog and memory problems
Anxiety, depression, or mood instability
Hormonal imbalances (e.g., PMS, thyroid issues)
Chronic inflammation or pain
Cardiovascular problems
Infertility or recurrent miscarriage
Migraines
Sensitivity to toxins or medications
These symptoms are often vague or misdiagnosed, which is why genetic testing and a comprehensive treatment plan can make a profound difference.
Need Testing and Lab Interpretation?
What Is the MTHFR Gene and What Does It Control?
Let’s break down the role of the MTHFR gene.
The MTHFR gene (short for methylenetetrahydrofolate reductase) plays a critical role in the body's methylation process. Methylation is a biochemical reaction that influences detoxification, hormone balance, neurotransmitter production, DNA repair, and immune function. Which is why you feel so run down despite your “normal” labs!
Specifically, the MTHFR gene helps convert folic acid into its active form—methylfolate—so it can be used effectively by your body. When the MTHFR gene is mutated, this process becomes impaired, which can cause negative effects across multiple systems.
Why Do Some People Have MTHFR Gene Mutations?
MTHFR mutations are inherited from one or both parents. Having one copy (heterozygous) or two copies (homozygous) of the mutation can affect how significantly your methylation process is disrupted. These mutations are relatively common—some estimates suggest up to 40% of the population may carry at least one variant. However, their impact varies based on overall health, environmental exposures, and lifestyle factors.
Epigenetics also play a role in symptom expression. Even if you have a mutation in the MTHFR gene—or other genes related to methylation—your environment, habits, and lifestyle have a huge influence on how those genes actually function. Epigenetics refers to changes in gene expression that don’t alter your DNA sequence but do affect how your genes turn on or off. This means your methylation pathways can be either supported or hindered by the choices you make every day.
For example, a nutrient-rich diet with natural folate and B12 supports healthy methylation, while synthetic folic acid or poor nutrition can impair it—especially for those with MTHFR mutations. Chronic stress, poor sleep, and toxin exposure can all strain the body’s ability to methylate efficiently. Alcohol, smoking, and inactivity also deplete vital methyl donors. On the other hand, balanced lifestyle choices like proper nutrition, restorative sleep, stress management, and moderate exercise can significantly improve methylation function—even if you carry a gene mutation.
Your Treatment Options: Personalized Supplement Plans by Dr. Malek
Dr. Malek helps patients correct methylation problems by creating tailored supplement plans based on genetic data.
Supplements help by providing targeted support to restore balance. They supply the specific nutrients and cofactors your body needs to keep the methylation cycle running smoothly. When your natural ability to process and activate these nutrients is compromised, supplements fill in the gaps, helping your system work around genetic obstacles.
These plans typically include:
Active forms of folate (such as methylfolate)
B-complex vitamins in bioavailable forms (like B12 as methylcobalamin)
Detox and antioxidant support (like glutathione and NAC)
Nutritional and lifestyle recommendations to reduce inflammation and support liver function
These treatment plans are carefully customized to your unique genetic profile, symptom picture, and health goals.
Going Beyond the MTHFR GENE with MTHFRSolve
Dr. Malek’s approach goes beyond just the MTHFR gene. MTHFRSolve tests for 28 different single nucleotide polymorphisms (SNPs) that impact:
Detox pathways (like COMT and GST)
Inflammation regulation (like TNF-alpha and IL-6)
Hormone metabolism (like CYP1B1 and SHBG)
Neurotransmitter balance (like MAO-A and GAD1)
While the MTHFR gene plays a key role in methylation, it's only one piece of a much larger puzzle. Many people get tested for MTHFR, find a mutation, and assume it explains everything—but true healing often requires looking deeper.
If you only test for MTHFR, you may miss other critical imbalances that are driving your symptoms—or that are preventing you from responding well to standard treatments.
By looking at your full genetic picture, Dr. Malek can provide a more targeted and effective plan—not just for methylation, but for long-term resilience and wellness.
Ready to Get Started with MTHFR Gene Mutation Treatment?
If you're ready to take a personalized, science-backed approach to your symptoms, schedule a consultation with Dr. Malek. Whether you're in Florida, Texas, Arizona, or Minnesota, support is available to help you better understand your genetics, support your body's natural systems, and feel like yourself again.
Your body has the blueprint for healing. We just need to listen to it.
