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The Slow COMT ROADMAP

Roadmaps to Health

As an early registrant, you get free access to future updates.

Supplements to Avoid with a Slow COMT
Malek Hamed, MD Malek Hamed, MD

Supplements to Avoid with a Slow COMT

As you may remember from our previous articles, catechol-O-methyltransferase (COMT) is an enzyme that breaks down catecholamines (most relevantly, dopamine), undesirable forms of estrogen, and other toxic substances in the body…

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Why You Probably Should Not Take SAMe
Malek Hamed, MD Malek Hamed, MD

Why You Probably Should Not Take SAMe

SAMe is found in virtually every single cell in your body.

It’s involved in producing neurotransmitters like serotonin and dopamine, detoxifying the liver from toxins and alcohol, supporting the gut-brain connection, and even regulating the expression of your own genetic code.

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How the COMT Gene Affects Your Susceptibility to Pain
Malek Hamed, MD Malek Hamed, MD

How the COMT Gene Affects Your Susceptibility to Pain

Pain is a very subjective experience. What barely perturbs one person can be enough to utterly upend another’s life entirely. This applies to physical pain—things like thorn pricks, broken bones, etc.—as well as emotional and psychological pain

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How NAC Can Help People with COMT Mutations
Malek Hamed, MD Malek Hamed, MD

How NAC Can Help People with COMT Mutations

Catechol-O-methyltransferase, or COMT as it’s more commonly known, is an enzyme that’s responsible for breaking down a variety of different compounds in the body. This includes things like: Dopamine—an important neurotransmitter…

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