Slow COMT function affects how the brain and body clear dopamine, norepinephrine, and estrogen—contributing to anxiety, fatigue, supplement intolerance, and poor sleep. This guide explains the full range of symptoms, why they’re often missed, and what works to stabilize those biochemical pathways.

Generally speaking, if you have a “mutation” in this gene, what that really means is that you have an under-functioning polymorphism that is less effective at breaking down dopamine, estrogen, and other metabolites…

As you may remember from our previous articles, catechol-O-methyltransferase (COMT) is an enzyme that breaks down catecholamines (most relevantly, dopamine), undesirable forms of estrogen, and other toxic substances in the body…

SAMe is found in virtually every single cell in your body.

It’s involved in producing neurotransmitters like serotonin and dopamine, detoxifying the liver from toxins and alcohol, supporting the gut-brain connection, and even regulating the expression of your own genetic code.

Pain is a very subjective experience. What barely perturbs one person can be enough to utterly upend another’s life entirely. This applies to physical pain—things like thorn pricks, broken bones, etc.—as well as emotional and psychological pain…

Coffee is not being used as it should. And this is problematic for everyone, but it is especially so for people with specific genetic variants.

Catechol-O-methyltransferase, or COMT as it’s more commonly known, is an enzyme that’s responsible for breaking down a variety of different compounds in the body. This includes things like: Dopamine—an important neurotransmitter…