MTHFR Test Popularized by Gary Brecka – What to Know
In recent years, the MTHFR gene test has gained serious attention—thanks in large part to wellness entrepreneur and biologist Gary Brecka. You may have heard about it on a podcast, social media, or in conversations about personalized supplements and peak performance. But what exactly is MTHFR? Why should you test for it? And how do you choose the right test for your needs?
Let’s answer the most common questions—and help you find the best MTHFR test for your health journey.
If you’re looking for a complete, easy-to-use MTHFR test, then click below
What is MTHFR?
MTHFR stands for methylenetetrahydrofolate reductase, a critical enzyme that helps your body process folate (vitamin B9) and convert it into its active form—methylfolate. This active form is essential for everything from detoxification and hormone balance to mood regulation and energy production.
When there’s a genetic mutation in the MTHFR gene, your body may not methylate properly. That means even if you're eating healthy or taking supplements, you might not be using key nutrients efficiently—leading to issues like fatigue, brain fog, anxiety, infertility, and more.
Why Do I Need to Test for MTHFR?
If you struggle with low energy, chronic inflammation, hormone imbalances, or even depression and anxiety, an MTHFR mutation could be part of the puzzle.
Testing for MTHFR helps you:
Understand how your body metabolizes B vitamins
Identify your methylation ability (which affects detox, brain function, and more)
Choose the right supplements (like methylated B12 and folate vs. folic acid)
Avoid unnecessary trial-and-error in your wellness routine
In short, it helps you biohack your health more effectively—with information that lasts a lifetime.
Who is Gary Brecka?
Gary Brecka is a human biologist and wellness expert who gained popularity for his work in epigenetics and longevity. He’s the co-founder of 10X Health and is known for working with elite athletes and celebrities.
What sets Brecka apart is his focus on using genetic testing to guide health decisions, especially tests that analyze how your body uses nutrients. He often says that optimizing genes like MTHFR can dramatically improve energy, cognition, and mood—and many of his followers report exactly that.
What Does Gary Brecka's MTHFR Test Look For?
Gary Brecka’s genetic testing kits typically focus on five core genes, including MTHFR. These genes are associated with:
Methylation
Inflammation
Detoxification
Vitamin utilization
Recovery and performance
His MTHFR test specifically looks at two common variants: C677T and A1298C. These variants affect how efficiently your body converts folic acid into methylfolate.
If you have one or both of these mutations, your body may need targeted support to bypass methylation bottlenecks—usually in the form of methylated nutrients.
However, the 10X methylation test is not the only test out there!
How Will I Feel After Fixing My MTHFR Issues?
People who address their MTHFR mutations with the right support often notice dramatic improvements in how they feel on a daily basis. The most common feedback includes:
Increased energy – When your body can finally methylate properly, it produces energy more efficiently at the cellular level. That means less fatigue, fewer crashes, and more stamina throughout the day.
Sharper mental clarity – Brain fog often lifts when your methylation pathways are supported. Improved neurotransmitter balance and detoxification help you think faster, focus longer, and feel mentally sharp.
More stable mood – MTHFR mutations can affect the production of serotonin, dopamine, and other mood-regulating chemicals. Once these systems are supported with the right forms of B vitamins and lifestyle adjustments, anxiety and irritability often decrease.
Improved sleep and stress resilience – Better methylation supports your ability to wind down at night and handle stress during the day. Cortisol levels become more regulated, and people report deeper, more restful sleep.
Better hormonal balance and fertility – MTHFR plays a role in hormone metabolism, detoxification, and reproductive health. Many women report more regular cycles, improved PMS symptoms, and even enhanced fertility when their methylation issues are addressed.
But let’s be honest—this isn’t a one-size-fits-all fix. You need to work with a doctor who truly knows you. For patients in Texas, Arizona, Florida, and Minnesotta, Dr. Malek can provide tailored wellness plans. Taking the right methylated supplements can help, but lasting transformation requires a consistent approach that includes clean nutrition, stress management, adequate sleep, and sometimes deeper detoxification support.
How Does the MTHFR Solve Kit Compare to Gary Brecka's Test?
Our test uses the same non-invasive cheek swab collection method as Gary Brecka’s 10X Health test—making it easy and painless to collect your DNA sample from the comfort of your home. While Brecka’s test analyzes five key genes related to methylation—MTHFR, COMT, AHCY, MTRR, and MTR—our Comprehensive Methylation Panel + COMT Testing Kit goes far beyond.
We assess over 20 genes involved in the methylation cycle, folate metabolism, detoxification, neurotransmitter production, and more. This expanded genetic insight allows for a more personalized, data-driven wellness plan. You’ll get actionable guidance on which supplements your body can actually use, how to fine-tune your nutrition, and what lifestyle changes may help you optimize energy, mental clarity, mood, and immune function.
If you’re looking for a deeper dive into your body’s biochemistry—not just methylation status, but how to improve it—our test gives you the full picture.
Ready to Start Your Methylation Journey?
Whether you’ve been struggling with vague symptoms or just want to upgrade your health strategy, testing your MTHFR gene is a smart place to start. And you don’t have to wait for a celebrity biohacker to guide you.
Visit MTHFR Solve to choose the kit that fits your needs and goals. You’ll get real answers, expert-backed recommendations, and a personalized roadmap to help you feel your best.
It’s time to stop guessing—and start solving.
